PharmacyCodes



Polycycline en es it fr

Polycycline Brand names, Polycycline Analogs

Polycycline Brand Names Mixture

  • Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
  • Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
  • Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)

Polycycline Chemical_Formula

C22H24N2O8

Polycycline RX_link

http://www.rxlist.com/cgi/generic2/tetcycl2.htm

Polycycline fda sheet

Polycycline msds (material safety sheet)

Polycycline MSDS

Polycycline Synthesis Reference

J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)

Polycycline Molecular Weight

444.435 g/mol

Polycycline Melting Point

165oC

Polycycline H2O Solubility

231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))

Polycycline State

Solid

Polycycline LogP

-0.304

Polycycline Dosage Forms

Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment

Polycycline Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.

Polycycline Pharmacology

Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.

Polycycline Absorption

Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.

Polycycline side effects and Toxicity

LD50=808mg/kg (orally in mice)

Polycycline Patient Information

Polycycline Organisms Affected

Enteric bacteria and other eubacteria