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Ciclibion Brand names, Ciclibion Analogs

Ciclibion Brand Names Mixture

  • Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
  • Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
  • Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)

Ciclibion Chemical_Formula

C22H24N2O8

Ciclibion RX_link

http://www.rxlist.com/cgi/generic2/tetcycl2.htm

Ciclibion fda sheet

Ciclibion msds (material safety sheet)

Ciclibion MSDS

Ciclibion Synthesis Reference

J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)

Ciclibion Molecular Weight

444.435 g/mol

Ciclibion Melting Point

165oC

Ciclibion H2O Solubility

231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))

Ciclibion State

Solid

Ciclibion LogP

-0.304

Ciclibion Dosage Forms

Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment

Ciclibion Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.

Ciclibion Pharmacology

Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.

Ciclibion Absorption

Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.

Ciclibion side effects and Toxicity

LD50=808mg/kg (orally in mice)

Ciclibion Patient Information

Ciclibion Organisms Affected

Enteric bacteria and other eubacteria