Tetracycline II
Brand names,
Tetracycline II
Analogs
Tetracycline II
Brand Names Mixture
- Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
- Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
- Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
- Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
- P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)
Tetracycline II
Chemical_Formula
C22H24N2O8
Tetracycline II
RX_link
http://www.rxlist.com/cgi/generic2/tetcycl2.htm
Tetracycline II
fda sheet
Tetracycline II
msds (material safety sheet)
Tetracycline II
Synthesis Reference
J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)
Tetracycline II
Molecular Weight
444.435 g/mol
Tetracycline II
Melting Point
165oC
Tetracycline II
H2O Solubility
231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))
Tetracycline II
State
Solid
Tetracycline II
LogP
-0.304
Tetracycline II
Dosage Forms
Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment
Tetracycline II
Indication
Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.
Tetracycline II
Pharmacology
Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.
Tetracycline II
Absorption
Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
Tetracycline II
side effects and Toxicity
LD50=808mg/kg (orally in mice)
Tetracycline II
Patient Information
Tetracycline II
Organisms Affected
Enteric bacteria and other eubacteria