Abramycin
Abramycin Brand names, Abramycin Analogs
- Abramycin
- Abricycline
- Achromycin
- Achromycin V
- Achromycin, Naphthacene Derivative
- Actisite
- Agromicina
- Ambramicina
- Ambramycin
- Amycin
- Anhydrotetracycline
- Aureomycin
- Bio-Tetra
- Biocycline
- Bristaciclin
- Bristaciclin α
- Bristaciclina
- Bristacycline
- Cefracycline
- Ciclibion
- Copharlan
- Criseociclina
- Cyclomycin
- Cyclopar
- Cytome
- Democracin
- Deschlorobiomycin
- Dumocyclin
- Enterocycline
- Hostacyclin
- Lexacycline
- Limecycline
- Liquamycin
- Medocycline
- Mericycline
- Micycline
- Neocycline
- Oletetrin
- Omegamycin
- Orlycycline
- Oxytetracycline HCl
- Panmycin
- Polycycline
- Polyotic
- Purocyclina
- Resteclin
- Retet
- Robitet
- Roviciclina
- SK-Tetracycline
- Solvocin
- Sumycin
- Sumycin Syrup
- TAC
- TC
- Terramycin
- Tetra-CO
- Tetrabon
- Tetrachel
- Tetracycl
- Tetracycline HCl
- Tetracycline II
- Tetracyn
- Tetradecin
- Tetrafil
- Tetramed
- Tetraverine
- Tetrex
- Topicycline
- Tsiklomistsin
- Tsiklomitsin
- Veracin
- Vetacyclinum
Abramycin Brand Names Mixture
- Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
- Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
- Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
- Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
- P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)
Abramycin Chemical_Formula
C22H24N2O8
Abramycin RX_link
http://www.rxlist.com/cgi/generic2/tetcycl2.htm
Abramycin fda sheet
Abramycin msds (material safety sheet)
Abramycin Synthesis Reference
J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)
Abramycin Molecular Weight
444.435 g/mol
Abramycin Melting Point
165oC
Abramycin H2O Solubility
231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))
Abramycin State
Solid
Abramycin LogP
-0.304
Abramycin Dosage Forms
Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment
Abramycin Indication
Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.
Abramycin Pharmacology
Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.
Abramycin Absorption
Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
Abramycin side effects and Toxicity
LD50=808mg/kg (orally in mice)
Abramycin Patient Information
Abramycin Organisms Affected
Enteric bacteria and other eubacteria
