Sulphadimethylisoxazole en es it fr

Sulphadimethylisoxazole Brand names, Sulphadimethylisoxazole Analogs

Sulphadimethylisoxazole Brand Names Mixture

  • Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
  • Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)

Sulphadimethylisoxazole Chemical_Formula


Sulphadimethylisoxazole RX_link

No information avaliable

Sulphadimethylisoxazole fda sheet

Sulphadimethylisoxazole msds (material safety sheet)

Sulphadimethylisoxazole MSDS

Sulphadimethylisoxazole Synthesis Reference

H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)

Sulphadimethylisoxazole Molecular Weight

267.305 g/mol

Sulphadimethylisoxazole Melting Point

194 oC

Sulphadimethylisoxazole H2O Solubility

0.13 mg/ml (25 oC)

Sulphadimethylisoxazole State


Sulphadimethylisoxazole LogP


Sulphadimethylisoxazole Dosage Forms

Tablet; Oral suspension; Eye drops

Sulphadimethylisoxazole Indication

Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Sulphadimethylisoxazole Pharmacology

Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Sulphadimethylisoxazole Absorption

No information avaliable

Sulphadimethylisoxazole side effects and Toxicity

LD50=6800 mg/kg (Orally in mice)

Sulphadimethylisoxazole Patient Information

Sulphadimethylisoxazole Organisms Affected

Enteric bacteria and other eubacteria