Tl-Azole

• Anti-Infectives
• Sulfonamides

• Accuzole
• Alphazole
• Amidoxal
• Astrazolo
• Azo Gantrisin
• Azosulfizin
• Bactesulf
• Barazae
• Chemouag
• Cosoxazole
• Dorsulfan
• Dorsulfan Warthausen
• Entusil
• Entusul
• G-Sox
• Ganda
• Gantrisin
• Gantrisine
• Gantrisona
• Gantrosan
• Isoxamin
• J-Sul
• Koro-Sulf
• Neazolin
• Neoxazol
• Norilgan-S
• Novazolo
• Novosaxazole
• Pancid
• Renosulfan
• Resoxol
• Roxosul
• Roxosul Tablets
• Roxoxol
• SI
• Saxosozine
• Sk-Soxazole
• Sodizole
• Sosol
• Soxamide
• Soxazole
• Soxisol
• Soxitabs
• Soxo
• Soxomide
• Stansin
• Sulbio
• Sulfadimethylisoxazole
• Sulfafurazol
• Sulfafurazole
• Sulfagan
• Sulfagen
• Sulfaisoxazole
• Sulfalar
• Sulfapolar
• Sulfasan
• Sulfasol
• Sulfasoxazole
• Sulfazin
• Sulfisin
• Sulfisonazole
• Sulfisoxasole
• Sulfisoxazol
• Sulfisoxazole Dialamine
• Sulfisoxazole Diolamine
• Sulfizin
• Sulfizol
• Sulfizole
• Sulfofurazole
• Sulfoxol
• Suloxsol
• Sulphadimethylisoxazole
• Sulphafuraz
• Sulphafurazol
• Sulphafurazole
• Sulphafurazolum
• Sulphaisoxazole
• Sulphisoxazol
• Sulphofurazole
• Sulsoxin
• Thiasin
• Tl-Azole
• Unisulf
• Urisoxin
• Uritrisin
• Urogan
• V-Sul
• Vagilia

• Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
• Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)

C₁₁H₁₃N₃O₃S

No information avaliable

Tl-Azole MSDS

H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)

267.305 g/mol

194 ^oC

0.13 mg/ml (25 oC)

Solid

2.569

Tablet; Oral suspension; Eye drops

Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

No information avaliable

LD₅₀=6800 mg/kg (Orally in mice)

Enteric bacteria and other eubacteria