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Sulphaisoxazole Brand names, Sulphaisoxazole Analogs

Sulphaisoxazole Brand Names Mixture

  • Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
  • Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)

Sulphaisoxazole Chemical_Formula


Sulphaisoxazole RX_link

No information avaliable

Sulphaisoxazole fda sheet

Sulphaisoxazole msds (material safety sheet)

Sulphaisoxazole MSDS

Sulphaisoxazole Synthesis Reference

H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)

Sulphaisoxazole Molecular Weight

267.305 g/mol

Sulphaisoxazole Melting Point

194 oC

Sulphaisoxazole H2O Solubility

0.13 mg/ml (25 oC)

Sulphaisoxazole State


Sulphaisoxazole LogP


Sulphaisoxazole Dosage Forms

Tablet; Oral suspension; Eye drops

Sulphaisoxazole Indication

Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Sulphaisoxazole Pharmacology

Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Sulphaisoxazole Absorption

No information avaliable

Sulphaisoxazole side effects and Toxicity

LD50=6800 mg/kg (Orally in mice)

Sulphaisoxazole Patient Information

Sulphaisoxazole Organisms Affected

Enteric bacteria and other eubacteria