Sulfisoxazole Dialamine
Brand names,
Sulfisoxazole Dialamine
Analogs
Sulfisoxazole Dialamine
Brand Names Mixture
- Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
- Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)
Sulfisoxazole Dialamine
Chemical_Formula
C11H13N3O3S
Sulfisoxazole Dialamine
RX_link
No information avaliable
Sulfisoxazole Dialamine
fda sheet
Sulfisoxazole Dialamine
msds (material safety sheet)
Sulfisoxazole Dialamine
Synthesis Reference
H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)
Sulfisoxazole Dialamine
Molecular Weight
267.305 g/mol
Sulfisoxazole Dialamine
Melting Point
194 oC
Sulfisoxazole Dialamine
H2O Solubility
0.13 mg/ml (25 oC)
Sulfisoxazole Dialamine
State
Solid
Sulfisoxazole Dialamine
LogP
2.569
Sulfisoxazole Dialamine
Dosage Forms
Tablet; Oral suspension; Eye drops
Sulfisoxazole Dialamine
Indication
Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Sulfisoxazole Dialamine
Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfisoxazole Dialamine
Absorption
No information avaliable
Sulfisoxazole Dialamine
side effects and Toxicity
LD50=6800 mg/kg (Orally in mice)
Sulfisoxazole Dialamine
Patient Information
Sulfisoxazole Dialamine
Organisms Affected
Enteric bacteria and other eubacteria