Gantrisona
Brand names,
Gantrisona
Analogs
Gantrisona
Brand Names Mixture
- Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
- Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)
Gantrisona
Chemical_Formula
C11H13N3O3S
Gantrisona
RX_link
No information avaliable
Gantrisona
fda sheet
Gantrisona
msds (material safety sheet)
Gantrisona
Synthesis Reference
H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)
Gantrisona
Molecular Weight
267.305 g/mol
Gantrisona
Melting Point
194 oC
Gantrisona
H2O Solubility
0.13 mg/ml (25 oC)
Gantrisona
State
Solid
Gantrisona
LogP
2.569
Gantrisona
Dosage Forms
Tablet; Oral suspension; Eye drops
Gantrisona
Indication
Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Gantrisona
Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Gantrisona
Absorption
No information avaliable
Gantrisona
side effects and Toxicity
LD50=6800 mg/kg (Orally in mice)
Gantrisona
Patient Information
Gantrisona
Organisms Affected
Enteric bacteria and other eubacteria