Sulfisoxazole Diolamine

Sulfisoxazole Diolamine Brand names, Sulfisoxazole Diolamine Analogs

Sulfisoxazole Diolamine Brand Names Mixture

Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)

Sulfisoxazole Diolamine Chemical_Formula

C₁₁H₁₃N₃O₃S

Sulfisoxazole Diolamine RX_link

No information avaliable

Sulfisoxazole Diolamine fda sheet

Sulfisoxazole Diolamine msds (material safety sheet)

Sulfisoxazole_Diolamine MSDS

Sulfisoxazole Diolamine Synthesis Reference

H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)

Sulfisoxazole Diolamine Molecular Weight

267.305 g/mol

Sulfisoxazole Diolamine Melting Point

194 ^oC

Sulfisoxazole Diolamine H₂O Solubility

0.13 mg/ml (25 oC)

Sulfisoxazole Diolamine State

Solid

Sulfisoxazole Diolamine LogP

2.569

Sulfisoxazole Diolamine Dosage Forms

Tablet; Oral suspension; Eye drops

Sulfisoxazole Diolamine Indication

Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Sulfisoxazole Diolamine Pharmacology

Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Sulfisoxazole Diolamine Absorption