Gantrisine
Brand names,
Gantrisine
Analogs
Gantrisine
Brand Names Mixture
- Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
- Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)
Gantrisine
Chemical_Formula
C11H13N3O3S
Gantrisine
RX_link
No information avaliable
Gantrisine
fda sheet
Gantrisine
msds (material safety sheet)
Gantrisine
Synthesis Reference
H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)
Gantrisine
Molecular Weight
267.305 g/mol
Gantrisine
Melting Point
194 oC
Gantrisine
H2O Solubility
0.13 mg/ml (25 oC)
Gantrisine
State
Solid
Gantrisine
LogP
2.569
Gantrisine
Dosage Forms
Tablet; Oral suspension; Eye drops
Gantrisine
Indication
Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Gantrisine
Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Gantrisine
Absorption
No information avaliable
Gantrisine
side effects and Toxicity
LD50=6800 mg/kg (Orally in mice)
Gantrisine
Patient Information
Gantrisine
Organisms Affected
Enteric bacteria and other eubacteria