Soxitabs
Brand names,
Soxitabs
Analogs
Soxitabs
Brand Names Mixture
- Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
- Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)
Soxitabs
Chemical_Formula
C11H13N3O3S
Soxitabs
RX_link
No information avaliable
Soxitabs
fda sheet
Soxitabs
msds (material safety sheet)
Soxitabs
Synthesis Reference
H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)
Soxitabs
Molecular Weight
267.305 g/mol
Soxitabs
Melting Point
194 oC
Soxitabs
H2O Solubility
0.13 mg/ml (25 oC)
Soxitabs
State
Solid
Soxitabs
LogP
2.569
Soxitabs
Dosage Forms
Tablet; Oral suspension; Eye drops
Soxitabs
Indication
Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Soxitabs
Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Soxitabs
Absorption
No information avaliable
Soxitabs
side effects and Toxicity
LD50=6800 mg/kg (Orally in mice)
Soxitabs
Patient Information
Soxitabs
Organisms Affected
Enteric bacteria and other eubacteria