Procanbid

Procanbid Brand names, Procanbid Analogs

Procanbid Brand Names Mixture

No information avaliable

Procanbid Chemical_Formula

C₁₃H₂₁N₃O

Procanbid RX_link

http://www.rxlist.com/cgi/generic3/procain.htm

Procanbid fda sheet

Procanbid msds (material safety sheet)

Procanbid MSDS

Procanbid Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Procanbid Molecular Weight

235.325 g/mol

Procanbid Melting Point

165-169 ^oC

Procanbid H₂O Solubility

5050 mg/L

Procanbid State

Solid

Procanbid LogP

1.282

Procanbid Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Procanbid Indication

For the treatment of life-threatening ventricular arrhythmias.

Procanbid Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Procanbid Absorption

75 to 95%

Procanbid side effects and Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Procanbid Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Procanbid Organisms Affected

Humans and other mammals