Procan Sr
Procan Sr Brand names, Procan Sr Analogs
Procan Sr Brand Names Mixture
- No information avaliable
Procan Sr Chemical_Formula
C13H21N3O
Procan Sr RX_link
http://www.rxlist.com/cgi/generic3/procain.htm
Procan Sr fda sheet
Procan Sr msds (material safety sheet)
Procan Sr Synthesis Reference
Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8
Procan Sr Molecular Weight
235.325 g/mol
Procan Sr Melting Point
165-169 oC
Procan Sr H2O Solubility
5050 mg/L
Procan Sr State
Solid
Procan Sr LogP
1.282
Procan Sr Dosage Forms
Capsule; Liquid; Solution; Tablet (extended-release)
Procan Sr Indication
For the treatment of life-threatening ventricular arrhythmias.
Procan Sr Pharmacology
Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.
Procan Sr Absorption
75 to 95%
Procan Sr side effects and Toxicity
LD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)
Procan Sr Patient Information
The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.
The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.
Procan Sr Organisms Affected
Humans and other mammals
