Procapan
Procapan Brand names, Procapan Analogs
Procapan Brand Names Mixture
- No information avaliable
Procapan Chemical_Formula
C13H21N3O
Procapan RX_link
http://www.rxlist.com/cgi/generic3/procain.htm
Procapan fda sheet
Procapan msds (material safety sheet)
Procapan Synthesis Reference
Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8
Procapan Molecular Weight
235.325 g/mol
Procapan Melting Point
165-169 oC
Procapan H2O Solubility
5050 mg/L
Procapan State
Solid
Procapan LogP
1.282
Procapan Dosage Forms
Capsule; Liquid; Solution; Tablet (extended-release)
Procapan Indication
For the treatment of life-threatening ventricular arrhythmias.
Procapan Pharmacology
Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.
Procapan Absorption
75 to 95%
Procapan side effects and Toxicity
LD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)
Procapan Patient Information
The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.
The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.
Procapan Organisms Affected
Humans and other mammals
