Procainamide Hcl

Procainamide Hcl Brand names, Procainamide Hcl Analogs

Procainamide Hcl Brand Names Mixture

No information avaliable

Procainamide Hcl Chemical_Formula

C₁₃H₂₁N₃O

Procainamide Hcl RX_link

http://www.rxlist.com/cgi/generic3/procain.htm

Procainamide Hcl fda sheet

Procainamide Hcl msds (material safety sheet)

Procainamide_Hcl MSDS

Procainamide Hcl Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Procainamide Hcl Molecular Weight

235.325 g/mol

Procainamide Hcl Melting Point

165-169 ^oC

Procainamide Hcl H₂O Solubility

5050 mg/L

Procainamide Hcl State

Solid

Procainamide Hcl LogP

1.282

Procainamide Hcl Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Procainamide Hcl Indication

For the treatment of life-threatening ventricular arrhythmias.

Procainamide Hcl Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Procainamide Hcl Absorption

75 to 95%

Procainamide Hcl side effects and Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Procainamide Hcl Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Procainamide Hcl Organisms Affected

Humans and other mammals