Promine

Promine Brand names, Promine Analogs

Promine Brand Names Mixture

No information avaliable

Promine Chemical_Formula

C₁₃H₂₁N₃O

Promine RX_link

http://www.rxlist.com/cgi/generic3/procain.htm

Promine fda sheet

Promine msds (material safety sheet)

Promine MSDS

Promine Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Promine Molecular Weight

235.325 g/mol

Promine Melting Point

165-169 ^oC

Promine H₂O Solubility

5050 mg/L

Promine State

Solid

Promine LogP

1.282

Promine Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Promine Indication

For the treatment of life-threatening ventricular arrhythmias.

Promine Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Promine Absorption

75 to 95%

Promine side effects and Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Promine Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Promine Organisms Affected

Humans and other mammals