Procan

Procan Brand names, Procan Analogs

Procan Brand Names Mixture

No information avaliable

Procan Chemical_Formula

C₁₃H₂₁N₃O

Procan RX_link

http://www.rxlist.com/cgi/generic3/procain.htm

Procan fda sheet

Procan msds (material safety sheet)

Procan MSDS

Procan Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Procan Molecular Weight

235.325 g/mol

Procan Melting Point

165-169 ^oC

Procan H₂O Solubility

5050 mg/L

Procan State

Solid

Procan LogP

1.282

Procan Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Procan Indication

For the treatment of life-threatening ventricular arrhythmias.

Procan Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Procan Absorption

75 to 95%

Procan side effects and Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Procan Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Procan Organisms Affected

Humans and other mammals