Pronestyl

Pronestyl Brand names, Pronestyl Analogs

Pronestyl Brand Names Mixture

No information avaliable

Pronestyl Chemical_Formula

C₁₃H₂₁N₃O

Pronestyl RX_link

http://www.rxlist.com/cgi/generic3/procain.htm

Pronestyl fda sheet

Pronestyl msds (material safety sheet)

Pronestyl MSDS

Pronestyl Synthesis Reference

Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8

Pronestyl Molecular Weight

235.325 g/mol

Pronestyl Melting Point

165-169 ^oC

Pronestyl H₂O Solubility

5050 mg/L

Pronestyl State

Solid

Pronestyl LogP

1.282

Pronestyl Dosage Forms

Capsule; Liquid; Solution; Tablet (extended-release)

Pronestyl Indication

For the treatment of life-threatening ventricular arrhythmias.

Pronestyl Pharmacology

Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.

Pronestyl Absorption

75 to 95%

Pronestyl side effects and Toxicity

LD₅₀=95 mg/kg (rat, IV); LD₅₀=312 mg/kg (mouse, oral); LD₅₀=103 mg/kg (mouse, IV); LD₅₀=250 mg/kg (rabbit, IV)

Pronestyl Patient Information

The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.

The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.

Pronestyl Organisms Affected

Humans and other mammals