Biocoryl
Biocoryl Brand names, Biocoryl Analogs
Biocoryl Brand Names Mixture
- No information avaliable
Biocoryl Chemical_Formula
C13H21N3O
Biocoryl RX_link
http://www.rxlist.com/cgi/generic3/procain.htm
Biocoryl fda sheet
Biocoryl msds (material safety sheet)
Biocoryl Synthesis Reference
Shannon SK et al., J Comb Chem. 2003 Nov-Dec;5(6):860-8
Biocoryl Molecular Weight
235.325 g/mol
Biocoryl Melting Point
165-169 oC
Biocoryl H2O Solubility
5050 mg/L
Biocoryl State
Solid
Biocoryl LogP
1.282
Biocoryl Dosage Forms
Capsule; Liquid; Solution; Tablet (extended-release)
Biocoryl Indication
For the treatment of life-threatening ventricular arrhythmias.
Biocoryl Pharmacology
Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected.
Biocoryl Absorption
75 to 95%
Biocoryl side effects and Toxicity
LD50=95 mg/kg (rat, IV); LD50=312 mg/kg (mouse, oral); LD50=103 mg/kg (mouse, IV); LD50=250 mg/kg (rabbit, IV)
Biocoryl Patient Information
The patient should be encouraged to disclose any past history of drug sensitivity, especially to procaine or other local anesthetic agents, or aspirin, and to report any history of kidney disease, congestive heart failure, myasthenia gravis, liver disease or lupus erythematosus.
The patient should be counseled to report any symptoms of arthralgia, myalgia, fever, chills, skin rash, easy bruising, sore throat or sore mouth, infections, dark urine or icterus, wheezing, muscular weakness, chest or abdominal pain, palpitations, nausea, vomiting, anorexia, diarrhea, hallucinations, dizziness or depression.
Biocoryl Organisms Affected
Humans and other mammals
