Pravastatin
Pravastatin Brand names, Pravastatin Analogs
Pravastatin Brand Names Mixture
- No information avaliable
Pravastatin Chemical_Formula
C23H36O7
Pravastatin RX_link
http://www.rxlist.com/cgi/generic/pravast.htm
Pravastatin fda sheet
Pravastatin msds (material safety sheet)
Pravastatin Synthesis Reference
A. Terahara, M.Tanaka, U.S. Pat. 4,346,227(1982)
Pravastatin Molecular Weight
424.528 g/mol
Pravastatin Melting Point
326oC
Pravastatin H2O Solubility
2464mg/L
Pravastatin State
Solid
Pravastatin LogP
2.613
Pravastatin Dosage Forms
Tablet
Pravastatin Indication
For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.
Pravastatin Pharmacology
Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.
Pravastatin Absorption
Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.
Pravastatin side effects and Toxicity
Rhabdomyolysis; LD50=mg/kg (orally in rat)
Pravastatin Patient Information
Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.
Pravastatin Organisms Affected
Humans and other mammals
