Pravastatina [Spanish]

Pravastatina [Spanish] Brand names, Pravastatina [Spanish] Analogs

Pravastatina [Spanish] Brand Names Mixture

No information avaliable

Pravastatina [Spanish] Chemical_Formula

C₂₃H₃₆O₇

Pravastatina [Spanish] RX_link

http://www.rxlist.com/cgi/generic/pravast.htm

Pravastatina [Spanish] fda sheet

Pravastatina_[Spanish] FDA

Pravastatina [Spanish] msds (material safety sheet)

Pravastatina [Spanish] Synthesis Reference

A. Terahara, M.Tanaka, U.S. Pat. 4,346,227(1982)

Pravastatina [Spanish] Molecular Weight

424.528 g/mol

Pravastatina [Spanish] Melting Point

326^oC

Pravastatina [Spanish] H₂O Solubility

2464mg/L

Pravastatina [Spanish] State

Solid

Pravastatina [Spanish] LogP

2.613

Pravastatina [Spanish] Dosage Forms

Tablet

Pravastatina [Spanish] Indication

For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.

Pravastatina [Spanish] Pharmacology

Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.

Pravastatina [Spanish] Absorption

Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.

Pravastatina [Spanish] side effects and Toxicity

Rhabdomyolysis; LD₅₀=mg/kg (orally in rat)

Pravastatina [Spanish] Patient Information

Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.

Pravastatina [Spanish] Organisms Affected

Humans and other mammals