Mevinolin
Mevinolin Brand names, Mevinolin Analogs
Mevinolin Brand Names Mixture
- No information avaliable
Mevinolin Chemical_Formula
C23H36O7
Mevinolin RX_link
http://www.rxlist.com/cgi/generic/pravast.htm
Mevinolin fda sheet
Mevinolin msds (material safety sheet)
Mevinolin Synthesis Reference
A. Terahara, M.Tanaka, U.S. Pat. 4,346,227(1982)
Mevinolin Molecular Weight
424.528 g/mol
Mevinolin Melting Point
326oC
Mevinolin H2O Solubility
2464mg/L
Mevinolin State
Solid
Mevinolin LogP
2.613
Mevinolin Dosage Forms
Tablet
Mevinolin Indication
For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.
Mevinolin Pharmacology
Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.
Mevinolin Absorption
Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.
Mevinolin side effects and Toxicity
Rhabdomyolysis; LD50=mg/kg (orally in rat)
Mevinolin Patient Information
Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.
Mevinolin Organisms Affected
Humans and other mammals
