Pravastatinum [Latin]

Pravastatinum [Latin] Brand names, Pravastatinum [Latin] Analogs

Pravastatinum [Latin] Brand Names Mixture

No information avaliable

Pravastatinum [Latin] Chemical_Formula

C₂₃H₃₆O₇

Pravastatinum [Latin] RX_link

http://www.rxlist.com/cgi/generic/pravast.htm

Pravastatinum [Latin] fda sheet

Pravastatinum_[Latin] FDA

Pravastatinum [Latin] msds (material safety sheet)

Pravastatinum [Latin] Synthesis Reference

A. Terahara, M.Tanaka, U.S. Pat. 4,346,227(1982)

Pravastatinum [Latin] Molecular Weight

424.528 g/mol

Pravastatinum [Latin] Melting Point

326^oC

Pravastatinum [Latin] H₂O Solubility

2464mg/L

Pravastatinum [Latin] State

Solid

Pravastatinum [Latin] LogP

2.613

Pravastatinum [Latin] Dosage Forms

Tablet

Pravastatinum [Latin] Indication

For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.

Pravastatinum [Latin] Pharmacology

Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.

Pravastatinum [Latin] Absorption

Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.

Pravastatinum [Latin] side effects and Toxicity

Rhabdomyolysis; LD₅₀=mg/kg (orally in rat)

Pravastatinum [Latin] Patient Information

Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.

Pravastatinum [Latin] Organisms Affected

Humans and other mammals