Fenmetrazin
Brand names,
Fenmetrazin
Analogs
Fenmetrazin
Brand Names Mixture
Fenmetrazin
Chemical_Formula
C11H15NO
Fenmetrazin
RX_link
No information avaliable
Fenmetrazin
fda sheet
Fenmetrazin
msds (material safety sheet)
Fenmetrazin
Synthesis Reference
No information avaliable
Fenmetrazin
Molecular Weight
177.243 g/mol
Fenmetrazin
Melting Point
139 oC
Fenmetrazin
H2O Solubility
>5 mg/L
Fenmetrazin
State
Solid
Fenmetrazin
LogP
1.796
Fenmetrazin
Dosage Forms
Tablet
Fenmetrazin
Indication
Used as an anorectic in the treatment of obesity.
Fenmetrazin
Pharmacology
Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.
Fenmetrazin
Absorption
Readily absorbed from the gastro-intestinal tract and buccal mucosa.
Fenmetrazin
side effects and Toxicity
Adult monkeys have an LD50 of 15 to 20 mg/kg, whereas for young monkeys the LD50 is only 5 mg/kg. Symptoms of overdose include acute central nervous system stimulation, cardiotoxicity causing tachycardia, arrhythmias, hypertension, and cardiovascular collapse. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L.
Fenmetrazin
Patient Information
No information avaliable
Fenmetrazin
Organisms Affected
Humans and other mammals