Cafilon
Brand names,
Cafilon
Analogs
Cafilon
Brand Names Mixture
Cafilon
Chemical_Formula
C11H15NO
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
177.243 g/mol
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Melting Point
139 oC
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H2O Solubility
>5 mg/L
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State
Solid
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LogP
1.796
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Dosage Forms
Tablet
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Indication
Used as an anorectic in the treatment of obesity.
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Pharmacology
Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.
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Absorption
Readily absorbed from the gastro-intestinal tract and buccal mucosa.
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side effects and Toxicity
Adult monkeys have an LD50 of 15 to 20 mg/kg, whereas for young monkeys the LD50 is only 5 mg/kg. Symptoms of overdose include acute central nervous system stimulation, cardiotoxicity causing tachycardia, arrhythmias, hypertension, and cardiovascular collapse. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals