Dexapos
Brand names,
Dexapos
Analogs
Dexapos
Brand Names Mixture
- Ak Trol Suspension (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
- Ciprodex (Ciprofloxacin (Ciprofloxacin Hydrochloride) + Dexamethasone)
- Cresophene Liq (Camphor + Chlorophenol + Dexamethasone + Thymol)
- Dioptrol Ointment (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
- Dioptrol Suspension (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
- Endomethasone Ivory (Dexamethasone + Hydrocortisone Acetate + Paraformaldehyde + Thymol Iodide)
- Maxitrol (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
- Maxitrol Ont (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
- Naquasone Bolus (Dexamethasone + Trichlormethiazide)
- Naquasone Inj (Dexamethasone + Trichlormethiazide)
- Neodecadron Eye Ear Soln 0.1% (Dexamethasone Phosphate (Dexamethasone Sodium Phosphate) + Neomycin Sulfate)
- Pendamine (Chlorpheniramine Maleate + Dexamethasone + Dihydrostreptomycin Sulfate + Penicillin G Procaine)
- Sandoz Opticort (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
- Septomixine Forte (Dexamethasone + Halethazole Tartrate + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate + Tyrothricin)
- Sofracort Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
- Sofracort Eye/Ear Drops (Dexamethasone Sodium Metasulphobenzoate + Framycetin Sulfate + Gramicidin)
- Sofracort Sterile Ear/Eye Drops (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
- Sofracort Sterile Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
- Tobradex Oph Ointment (Dexamethasone + Tobramycin)
- Tobradex Oph Sus (Dexamethasone + Tobramycin)
- Tresaderm Dermatologic Solution (Dexamethasone + Neomycin (Neomycin Sulfate) + Thiabendazole)
Dexapos
Chemical_Formula
C22H29FO5
Dexapos
RX_link
http://www.rxlist.com/cgi/generic/dexameth.htm
Dexapos
fda sheet
Dexapos
msds (material safety sheet)
Dexapos
Synthesis Reference
Chemerda et al.; U.S. Pat. 2,939,873 (1960)
Dexapos
Molecular Weight
392.461 g/mol
Dexapos
Melting Point
262 oC
Dexapos
H2O Solubility
89 mg/L
Dexapos
State
Solid
Dexapos
LogP
1.772
Dexapos
Dosage Forms
Drops; Elixir; Implant; Liquid; Ointment; Powder; Solution; Tablet
Dexapos
Indication
Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
Dexapos
Pharmacology
Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.
Dexapos
Absorption
80-90%
Dexapos
side effects and Toxicity
Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.
Dexapos
Patient Information
Dexapos
Organisms Affected
Humans and other mammals