Dexacortal

Dexacortal Brand names, Dexacortal Analogs

Dexacortal Brand Names Mixture

Ak Trol Suspension (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
Ciprodex (Ciprofloxacin (Ciprofloxacin Hydrochloride) + Dexamethasone)
Cresophene Liq (Camphor + Chlorophenol + Dexamethasone + Thymol)
Dioptrol Ointment (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
Dioptrol Suspension (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
Endomethasone Ivory (Dexamethasone + Hydrocortisone Acetate + Paraformaldehyde + Thymol Iodide)
Maxitrol (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
Maxitrol Ont (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
Naquasone Bolus (Dexamethasone + Trichlormethiazide)
Naquasone Inj (Dexamethasone + Trichlormethiazide)
Neodecadron Eye Ear Soln 0.1% (Dexamethasone Phosphate (Dexamethasone Sodium Phosphate) + Neomycin Sulfate)
Pendamine (Chlorpheniramine Maleate + Dexamethasone + Dihydrostreptomycin Sulfate + Penicillin G Procaine)
Sandoz Opticort (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
Septomixine Forte (Dexamethasone + Halethazole Tartrate + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate + Tyrothricin)
Sofracort Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
Sofracort Eye/Ear Drops (Dexamethasone Sodium Metasulphobenzoate + Framycetin Sulfate + Gramicidin)
Sofracort Sterile Ear/Eye Drops (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
Sofracort Sterile Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
Tobradex Oph Ointment (Dexamethasone + Tobramycin)
Tobradex Oph Sus (Dexamethasone + Tobramycin)
Tresaderm Dermatologic Solution (Dexamethasone + Neomycin (Neomycin Sulfate) + Thiabendazole)

Dexacortal Chemical_Formula

C₂₂H₂₉FO₅

Dexacortal RX_link

http://www.rxlist.com/cgi/generic/dexameth.htm

Dexacortal fda sheet

Dexacortal FDA

Dexacortal msds (material safety sheet)

Dexacortal MSDS

Dexacortal Synthesis Reference

Chemerda et al.; U.S. Pat. 2,939,873 (1960)

Dexacortal Molecular Weight

392.461 g/mol

Dexacortal Melting Point

262 ^oC

Dexacortal H₂O Solubility

89 mg/L

Dexacortal State

Solid

Dexacortal LogP

1.772

Dexacortal Dosage Forms

Drops; Elixir; Implant; Liquid; Ointment; Powder; Solution; Tablet

Dexacortal Indication

Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.

Dexacortal Pharmacology

Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.

Dexacortal Absorption

80-90%

Dexacortal side effects and Toxicity

Oral, rat LD₅₀: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.

Dexacortal Patient Information

Dexacortal Organisms Affected

Humans and other mammals