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Aphthasolone Brand names, Aphthasolone Analogs

Aphthasolone Brand Names Mixture

  • Ak Trol Suspension (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
  • Ciprodex (Ciprofloxacin (Ciprofloxacin Hydrochloride) + Dexamethasone)
  • Cresophene Liq (Camphor + Chlorophenol + Dexamethasone + Thymol)
  • Dioptrol Ointment (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
  • Dioptrol Suspension (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
  • Endomethasone Ivory (Dexamethasone + Hydrocortisone Acetate + Paraformaldehyde + Thymol Iodide)
  • Maxitrol (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
  • Maxitrol Ont (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
  • Naquasone Bolus (Dexamethasone + Trichlormethiazide)
  • Naquasone Inj (Dexamethasone + Trichlormethiazide)
  • Neodecadron Eye Ear Soln 0.1% (Dexamethasone Phosphate (Dexamethasone Sodium Phosphate) + Neomycin Sulfate)
  • Pendamine (Chlorpheniramine Maleate + Dexamethasone + Dihydrostreptomycin Sulfate + Penicillin G Procaine)
  • Sandoz Opticort (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
  • Septomixine Forte (Dexamethasone + Halethazole Tartrate + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate + Tyrothricin)
  • Sofracort Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
  • Sofracort Eye/Ear Drops (Dexamethasone Sodium Metasulphobenzoate + Framycetin Sulfate + Gramicidin)
  • Sofracort Sterile Ear/Eye Drops (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
  • Sofracort Sterile Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
  • Tobradex Oph Ointment (Dexamethasone + Tobramycin)
  • Tobradex Oph Sus (Dexamethasone + Tobramycin)
  • Tresaderm Dermatologic Solution (Dexamethasone + Neomycin (Neomycin Sulfate) + Thiabendazole)

Aphthasolone Chemical_Formula

C22H29FO5

Aphthasolone RX_link

http://www.rxlist.com/cgi/generic/dexameth.htm

Aphthasolone fda sheet

Aphthasolone FDA

Aphthasolone msds (material safety sheet)

Aphthasolone MSDS

Aphthasolone Synthesis Reference

Chemerda et al.; U.S. Pat. 2,939,873 (1960)

Aphthasolone Molecular Weight

392.461 g/mol

Aphthasolone Melting Point

262 oC

Aphthasolone H2O Solubility

89 mg/L

Aphthasolone State

Solid

Aphthasolone LogP

1.772

Aphthasolone Dosage Forms

Drops; Elixir; Implant; Liquid; Ointment; Powder; Solution; Tablet

Aphthasolone Indication

Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.

Aphthasolone Pharmacology

Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.

Aphthasolone Absorption

80-90%

Aphthasolone side effects and Toxicity

Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.

Aphthasolone Patient Information

Aphthasolone Organisms Affected

Humans and other mammals