Dexa-Cortisyl
Brand names,
Dexa-Cortisyl
Analogs
Dexa-Cortisyl
Brand Names Mixture
- Ak Trol Suspension (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
- Ciprodex (Ciprofloxacin (Ciprofloxacin Hydrochloride) + Dexamethasone)
- Cresophene Liq (Camphor + Chlorophenol + Dexamethasone + Thymol)
- Dioptrol Ointment (Dexamethasone + Neomycin Sulfate + Polymyxin B Sulfate)
- Dioptrol Suspension (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
- Endomethasone Ivory (Dexamethasone + Hydrocortisone Acetate + Paraformaldehyde + Thymol Iodide)
- Maxitrol (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
- Maxitrol Ont (Dexamethasone + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate)
- Naquasone Bolus (Dexamethasone + Trichlormethiazide)
- Naquasone Inj (Dexamethasone + Trichlormethiazide)
- Neodecadron Eye Ear Soln 0.1% (Dexamethasone Phosphate (Dexamethasone Sodium Phosphate) + Neomycin Sulfate)
- Pendamine (Chlorpheniramine Maleate + Dexamethasone + Dihydrostreptomycin Sulfate + Penicillin G Procaine)
- Sandoz Opticort (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
- Septomixine Forte (Dexamethasone + Halethazole Tartrate + Neomycin (Neomycin Sulfate) + Polymyxin B Sulfate + Tyrothricin)
- Sofracort Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
- Sofracort Eye/Ear Drops (Dexamethasone Sodium Metasulphobenzoate + Framycetin Sulfate + Gramicidin)
- Sofracort Sterile Ear/Eye Drops (Dexamethasone (Dexamethasone Sodium Metasulphobenzoate) + Framycetin Sulfate + Gramicidin)
- Sofracort Sterile Ear/Eye Ointment (Dexamethasone + Framycetin Sulfate + Gramicidin)
- Tobradex Oph Ointment (Dexamethasone + Tobramycin)
- Tobradex Oph Sus (Dexamethasone + Tobramycin)
- Tresaderm Dermatologic Solution (Dexamethasone + Neomycin (Neomycin Sulfate) + Thiabendazole)
Dexa-Cortisyl
Chemical_Formula
C22H29FO5
Dexa-Cortisyl
RX_link
http://www.rxlist.com/cgi/generic/dexameth.htm
Dexa-Cortisyl
fda sheet
Dexa-Cortisyl
msds (material safety sheet)
Dexa-Cortisyl
Synthesis Reference
Chemerda et al.; U.S. Pat. 2,939,873 (1960)
Dexa-Cortisyl
Molecular Weight
392.461 g/mol
Dexa-Cortisyl
Melting Point
262 oC
Dexa-Cortisyl
H2O Solubility
89 mg/L
Dexa-Cortisyl
State
Solid
Dexa-Cortisyl
LogP
1.772
Dexa-Cortisyl
Dosage Forms
Drops; Elixir; Implant; Liquid; Ointment; Powder; Solution; Tablet
Dexa-Cortisyl
Indication
Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
Dexa-Cortisyl
Pharmacology
Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.
Dexa-Cortisyl
Absorption
80-90%
Dexa-Cortisyl
side effects and Toxicity
Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.
Dexa-Cortisyl
Patient Information
Dexa-Cortisyl
Organisms Affected
Humans and other mammals