Categorie
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Analogs
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Les marques melange
No information avaliable
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Formule chimique
C26H28Cl2N4O4
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RX lien
http://www.rxlist.com/cgi/generic/ketocon.htm
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
J. Heeres et al., US. 4,144,346 (1979)
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Poids moleculaire
531.43 g/mol
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Point de fusion
146 oC
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H2O Solubilite
0,0866 mg / L
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Etat
Solid
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LogP
3.651
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Formes pharmaceutiques
Comprimés; Shampooing; Crème; Suspension
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Indication
Pour le traitement des éléments suivants infections fongiques systémiques: la candidose chronique candidose cutanéomuqueuse, muguet, candidurie, blastomycose, coccidioïdomycose, histoplasmose, chromomycose et paracoccidioidomycosis.
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Pharmacologie
Le kétoconazole, comme le clotrimazole, le fluconazole, itraconazole, le miconazole et le, est un agent antifongique imidazole.
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Absorption
Modérée
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Toxicite
Hépatotoxicité, DL50 = 86 mg / kg (par voie orale chez le rat)
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Information pour les patients
Shampoo: May be irritating to mucous membranes of the eyes and contact with this area should be
avoided.
There have been reports that use of the shampoo resulted in removal of the curl from permanently waved hair.
Tablet: Patients should be instructed to report any signs and symptoms which may suggest liver
dysfunction so that appropriate biochemical testing can be done. Such signs and symptoms may include unusual fatigue,
anorexia, nausea and/or vomiting, jaundice, dark urine or pale stools
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Organismes affectes
Champignons