Nizoral a-D Shampoo
Brand names,
Nizoral a-D Shampoo
Analogs
Nizoral a-D Shampoo
Brand Names Mixture
Nizoral a-D Shampoo
Chemical_Formula
C26H28Cl2N4O4
Nizoral a-D Shampoo
RX_link
http://www.rxlist.com/cgi/generic/ketocon.htm
Nizoral a-D Shampoo
fda sheet
Nizoral a-D Shampoo
msds (material safety sheet)
Nizoral a-D Shampoo
Synthesis Reference
J. Heeres et al., U.S. Pat. 4,144,346 (1979)
Nizoral a-D Shampoo
Molecular Weight
531.43 g/mol
Nizoral a-D Shampoo
Melting Point
146 oC
Nizoral a-D Shampoo
H2O Solubility
0.0866 mg/L
Nizoral a-D Shampoo
State
Solid
Nizoral a-D Shampoo
LogP
3.651
Nizoral a-D Shampoo
Dosage Forms
Tablets; Shampoo; Cream; Suspension
Nizoral a-D Shampoo
Indication
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Nizoral a-D Shampoo
Pharmacology
Ketoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Nizoral a-D Shampoo
Absorption
Moderate
Nizoral a-D Shampoo
side effects and Toxicity
Hepatotoxicity, LD50=86 mg/kg (orally in rat)
Nizoral a-D Shampoo
Patient Information
Shampoo: May be irritating to mucous membranes of the eyes and contact with this area should be
avoided.
There have been reports that use of the shampoo resulted in removal of the curl from permanently waved hair.
Tablet: Patients should be instructed to report any signs and symptoms which may suggest liver
dysfunction so that appropriate biochemical testing can be done. Such signs and symptoms may include unusual fatigue,
anorexia, nausea and/or vomiting, jaundice, dark urine or pale stools
Nizoral a-D Shampoo
Organisms Affected
Fungi