Nizoral Cream
Brand names,
Nizoral Cream
Analogs
Nizoral Cream
Brand Names Mixture
Nizoral Cream
Chemical_Formula
C26H28Cl2N4O4
Nizoral Cream
RX_link
http://www.rxlist.com/cgi/generic/ketocon.htm
Nizoral Cream
fda sheet
Nizoral Cream
msds (material safety sheet)
Nizoral Cream
Synthesis Reference
J. Heeres et al., U.S. Pat. 4,144,346 (1979)
Nizoral Cream
Molecular Weight
531.43 g/mol
Nizoral Cream
Melting Point
146 oC
Nizoral Cream
H2O Solubility
0.0866 mg/L
Nizoral Cream
State
Solid
Nizoral Cream
LogP
3.651
Nizoral Cream
Dosage Forms
Tablets; Shampoo; Cream; Suspension
Nizoral Cream
Indication
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Nizoral Cream
Pharmacology
Ketoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Nizoral Cream
Absorption
Moderate
Nizoral Cream
side effects and Toxicity
Hepatotoxicity, LD50=86 mg/kg (orally in rat)
Nizoral Cream
Patient Information
Shampoo: May be irritating to mucous membranes of the eyes and contact with this area should be
avoided.
There have been reports that use of the shampoo resulted in removal of the curl from permanently waved hair.
Tablet: Patients should be instructed to report any signs and symptoms which may suggest liver
dysfunction so that appropriate biochemical testing can be done. Such signs and symptoms may include unusual fatigue,
anorexia, nausea and/or vomiting, jaundice, dark urine or pale stools
Nizoral Cream
Organisms Affected
Fungi