Ketoconazol
Ketoconazol Brand names, Ketoconazol Analogs
Ketoconazol Brand Names Mixture
- No information avaliable
Ketoconazol Chemical_Formula
C26H28Cl2N4O4
Ketoconazol RX_link
http://www.rxlist.com/cgi/generic/ketocon.htm
Ketoconazol fda sheet
Ketoconazol msds (material safety sheet)
Ketoconazol Synthesis Reference
J. Heeres et al., U.S. Pat. 4,144,346 (1979)
Ketoconazol Molecular Weight
531.43 g/mol
Ketoconazol Melting Point
146 oC
Ketoconazol H2O Solubility
0.0866 mg/L
Ketoconazol State
Solid
Ketoconazol LogP
3.651
Ketoconazol Dosage Forms
Tablets; Shampoo; Cream; Suspension
Ketoconazol Indication
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Ketoconazol Pharmacology
Ketoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Ketoconazol Absorption
Moderate
Ketoconazol side effects and Toxicity
Hepatotoxicity, LD50=86 mg/kg (orally in rat)
Ketoconazol Patient Information
Shampoo: May be irritating to mucous membranes of the eyes and contact with this area should be avoided.
There have been reports that use of the shampoo resulted in removal of the curl from permanently waved hair.
Tablet: Patients should be instructed to report any signs and symptoms which may suggest liver dysfunction so that appropriate biochemical testing can be done. Such signs and symptoms may include unusual fatigue, anorexia, nausea and/or vomiting, jaundice, dark urine or pale stools
Ketoconazol Organisms Affected
Fungi
