Orifungal
Orifungal Brand names, Orifungal Analogs
Orifungal Brand Names Mixture
- No information avaliable
Orifungal Chemical_Formula
C26H28Cl2N4O4
Orifungal RX_link
http://www.rxlist.com/cgi/generic/ketocon.htm
Orifungal fda sheet
Orifungal msds (material safety sheet)
Orifungal Synthesis Reference
J. Heeres et al., U.S. Pat. 4,144,346 (1979)
Orifungal Molecular Weight
531.43 g/mol
Orifungal Melting Point
146 oC
Orifungal H2O Solubility
0.0866 mg/L
Orifungal State
Solid
Orifungal LogP
3.651
Orifungal Dosage Forms
Tablets; Shampoo; Cream; Suspension
Orifungal Indication
For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Orifungal Pharmacology
Ketoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Orifungal Absorption
Moderate
Orifungal side effects and Toxicity
Hepatotoxicity, LD50=86 mg/kg (orally in rat)
Orifungal Patient Information
Shampoo: May be irritating to mucous membranes of the eyes and contact with this area should be avoided.
There have been reports that use of the shampoo resulted in removal of the curl from permanently waved hair.
Tablet: Patients should be instructed to report any signs and symptoms which may suggest liver dysfunction so that appropriate biochemical testing can be done. Such signs and symptoms may include unusual fatigue, anorexia, nausea and/or vomiting, jaundice, dark urine or pale stools
Orifungal Organisms Affected
Fungi
