Vitamin K1 (VAN)
Brand names,
Vitamin K1 (VAN)
Analogs
Vitamin K1 (VAN)
Brand Names Mixture
Vitamin K1 (VAN)
Chemical_Formula
C31H46O2
Vitamin K1 (VAN)
RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Vitamin K1 (VAN)
fda sheet
Vitamin K1 (VAN)
msds (material safety sheet)
Vitamin K1 (VAN)
Synthesis Reference
No information avaliable
Vitamin K1 (VAN)
Molecular Weight
450.696 g/mol
Vitamin K1 (VAN)
Melting Point
-20 oC
Vitamin K1 (VAN)
H2O Solubility
Insoluble in water
Vitamin K1 (VAN)
State
Liquid
Vitamin K1 (VAN)
LogP
8.841
Vitamin K1 (VAN)
Dosage Forms
Liquid
Vitamin K1 (VAN)
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Vitamin K1 (VAN)
Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Vitamin K1 (VAN)
Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Vitamin K1 (VAN)
side effects and Toxicity
No information avaliable
Vitamin K1 (VAN)
Patient Information
No information avaliable
Vitamin K1 (VAN)
Organisms Affected
Humans and other mammals