Antihemorrhagic vitamin
Brand names,
Antihemorrhagic vitamin
Analogs
Antihemorrhagic vitamin
Brand Names Mixture
Antihemorrhagic vitamin
Chemical_Formula
C31H46O2
Antihemorrhagic vitamin
RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Antihemorrhagic vitamin
fda sheet
Antihemorrhagic vitamin
msds (material safety sheet)
Antihemorrhagic vitamin
Synthesis Reference
No information avaliable
Antihemorrhagic vitamin
Molecular Weight
450.696 g/mol
Antihemorrhagic vitamin
Melting Point
-20 oC
Antihemorrhagic vitamin
H2O Solubility
Insoluble in water
Antihemorrhagic vitamin
State
Liquid
Antihemorrhagic vitamin
LogP
8.841
Antihemorrhagic vitamin
Dosage Forms
Liquid
Antihemorrhagic vitamin
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Antihemorrhagic vitamin
Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Antihemorrhagic vitamin
Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Antihemorrhagic vitamin
side effects and Toxicity
No information avaliable
Antihemorrhagic vitamin
Patient Information
No information avaliable
Antihemorrhagic vitamin
Organisms Affected
Humans and other mammals