Synthex P
Brand names,
Synthex P
Analogs
Synthex P
Brand Names Mixture
Synthex P
Chemical_Formula
C31H46O2
Synthex P
RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Synthex P
fda sheet
Synthex P
msds (material safety sheet)
Synthex P
Synthesis Reference
No information avaliable
Synthex P
Molecular Weight
450.696 g/mol
Synthex P
Melting Point
-20 oC
Synthex P
H2O Solubility
Insoluble in water
Synthex P
State
Liquid
Synthex P
LogP
8.841
Synthex P
Dosage Forms
Liquid
Synthex P
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Synthex P
Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Synthex P
Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Synthex P
side effects and Toxicity
No information avaliable
Synthex P
Patient Information
No information avaliable
Synthex P
Organisms Affected
Humans and other mammals