Phythyl-menadion
Brand names,
Phythyl-menadion
Analogs
Phythyl-menadion
Brand Names Mixture
Phythyl-menadion
Chemical_Formula
C31H46O2
Phythyl-menadion
RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Phythyl-menadion
fda sheet
Phythyl-menadion
msds (material safety sheet)
Phythyl-menadion
Synthesis Reference
No information avaliable
Phythyl-menadion
Molecular Weight
450.696 g/mol
Phythyl-menadion
Melting Point
-20 oC
Phythyl-menadion
H2O Solubility
Insoluble in water
Phythyl-menadion
State
Liquid
Phythyl-menadion
LogP
8.841
Phythyl-menadion
Dosage Forms
Liquid
Phythyl-menadion
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Phythyl-menadion
Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Phythyl-menadion
Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Phythyl-menadion
side effects and Toxicity
No information avaliable
Phythyl-menadion
Patient Information
No information avaliable
Phythyl-menadion
Organisms Affected
Humans and other mammals