Kativ N
Brand names,
Kativ N
Analogs
Kativ N
Brand Names Mixture
Kativ N
Chemical_Formula
C31H46O2
Kativ N
RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Kativ N
fda sheet
Kativ N
msds (material safety sheet)
Kativ N
Synthesis Reference
No information avaliable
Kativ N
Molecular Weight
450.696 g/mol
Kativ N
Melting Point
-20 oC
Kativ N
H2O Solubility
Insoluble in water
Kativ N
State
Liquid
Kativ N
LogP
8.841
Kativ N
Dosage Forms
Liquid
Kativ N
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Kativ N
Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Kativ N
Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Kativ N
side effects and Toxicity
No information avaliable
Kativ N
Patient Information
No information avaliable
Kativ N
Organisms Affected
Humans and other mammals