Aqua-Mephytin
Brand names,
Aqua-Mephytin
Analogs
Aqua-Mephytin
Brand Names Mixture
Aqua-Mephytin
Chemical_Formula
C31H46O2
Aqua-Mephytin
RX_link
http://www.rxlist.com/cgi/generic3/phytonadione.htm
Aqua-Mephytin
fda sheet
Aqua-Mephytin
msds (material safety sheet)
Aqua-Mephytin
Synthesis Reference
No information avaliable
Aqua-Mephytin
Molecular Weight
450.696 g/mol
Aqua-Mephytin
Melting Point
-20 oC
Aqua-Mephytin
H2O Solubility
Insoluble in water
Aqua-Mephytin
State
Liquid
Aqua-Mephytin
LogP
8.841
Aqua-Mephytin
Dosage Forms
Liquid
Aqua-Mephytin
Indication
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Aqua-Mephytin
Pharmacology
Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).
Aqua-Mephytin
Absorption
Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Aqua-Mephytin
side effects and Toxicity
No information avaliable
Aqua-Mephytin
Patient Information
No information avaliable
Aqua-Mephytin
Organisms Affected
Humans and other mammals