Uroz
Brand names,
Uroz
Analogs
Uroz
Brand Names Mixture
Uroz
Chemical_Formula
C9H10N4O2S2
Uroz
RX_link
No information avaliable
Uroz
fda sheet
Uroz
msds (material safety sheet)
Uroz
Synthesis Reference
No information avaliable
Uroz
Molecular Weight
270.333 g/mol
Uroz
Melting Point
208 oC
Uroz
H2O Solubility
1050 mg/L
Uroz
State
Solid
Uroz
LogP
2.968
Uroz
Dosage Forms
Tablet
Uroz
Indication
For the treatment of urinary tract infection
Uroz
Pharmacology
Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Uroz
Absorption
Rapidly absorbed.
Uroz
side effects and Toxicity
No information avaliable
Uroz
Patient Information
Uroz
Organisms Affected
Enteric bacteria and other eubacteria