Rufol
Brand names,
Rufol
Analogs
Rufol
Brand Names Mixture
Rufol
Chemical_Formula
C9H10N4O2S2
Rufol
RX_link
No information avaliable
Rufol
fda sheet
Rufol
msds (material safety sheet)
Rufol
Synthesis Reference
No information avaliable
Rufol
Molecular Weight
270.333 g/mol
Rufol
Melting Point
208 oC
Rufol
H2O Solubility
1050 mg/L
Rufol
State
Solid
Rufol
LogP
2.968
Rufol
Dosage Forms
Tablet
Rufol
Indication
For the treatment of urinary tract infection
Rufol
Pharmacology
Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Rufol
Absorption
Rapidly absorbed.
Rufol
side effects and Toxicity
No information avaliable
Rufol
Patient Information
Rufol
Organisms Affected
Enteric bacteria and other eubacteria