Sulphamethizole

• Anti-Infectives
• ATC:B05CA04
• ATC:D06BA04
• ATC:J01EB02
• ATC:S01AB01

• Ayerlucil
• Famet
• Lucosil
• Methazol
• Microsul
• Proklar
• Renasul
• Rufol
• SULFAMETHIAZOLE
• Salimol
• Solfametizolo [Dcit]
• Sulamethizole
• Sulfa Gram
• Sulfamethazole
• Sulfamethizol
• Sulfamethizole [Usan:Inn:Jan]
• Sulfamethizolum [Inn-Latin]
• Sulfamethylthiadiazole
• Sulfametizol [Inn-Spanish]
• Sulfapyelon
• Sulfstat
• Sulfurine
• Sulphamethizole
• Sulphamethyltiadiazole
• Tetracid
• Thidicur
• Thiosulfil
• Thiosulfil Forte
• Ultrasul
• Urocydal
• Urodiaton
• Urolucosil
• Urosulfin
• Uroz

• No information avaliable

C₉H₁₀N₄O₂S₂

No information avaliable

No information avaliable

270.333 g/mol

208 ^oC

1050 mg/L

Solid

2.968

Tablet

For the treatment of urinary tract infection

Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Rapidly absorbed.

No information avaliable

Enteric bacteria and other eubacteria