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SULFAMETHIAZOLE Brand names, SULFAMETHIAZOLE Analogs

SULFAMETHIAZOLE Brand Names Mixture

  • No information avaliable

SULFAMETHIAZOLE Chemical_Formula

C9H10N4O2S2

SULFAMETHIAZOLE RX_link

No information avaliable

SULFAMETHIAZOLE fda sheet

SULFAMETHIAZOLE msds (material safety sheet)

SULFAMETHIAZOLE Synthesis Reference

No information avaliable

SULFAMETHIAZOLE Molecular Weight

270.333 g/mol

SULFAMETHIAZOLE Melting Point

208 oC

SULFAMETHIAZOLE H2O Solubility

1050 mg/L

SULFAMETHIAZOLE State

Solid

SULFAMETHIAZOLE LogP

2.968

SULFAMETHIAZOLE Dosage Forms

Tablet

SULFAMETHIAZOLE Indication

For the treatment of urinary tract infection

SULFAMETHIAZOLE Pharmacology

Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

SULFAMETHIAZOLE Absorption

Rapidly absorbed.

SULFAMETHIAZOLE side effects and Toxicity

No information avaliable

SULFAMETHIAZOLE Patient Information

SULFAMETHIAZOLE Organisms Affected

Enteric bacteria and other eubacteria