Thidicur
Brand names,
Thidicur
Analogs
Thidicur
Brand Names Mixture
Thidicur
Chemical_Formula
C9H10N4O2S2
Thidicur
RX_link
No information avaliable
Thidicur
fda sheet
Thidicur
msds (material safety sheet)
Thidicur
Synthesis Reference
No information avaliable
Thidicur
Molecular Weight
270.333 g/mol
Thidicur
Melting Point
208 oC
Thidicur
H2O Solubility
1050 mg/L
Thidicur
State
Solid
Thidicur
LogP
2.968
Thidicur
Dosage Forms
Tablet
Thidicur
Indication
For the treatment of urinary tract infection
Thidicur
Pharmacology
Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Thidicur
Absorption
Rapidly absorbed.
Thidicur
side effects and Toxicity
No information avaliable
Thidicur
Patient Information
Thidicur
Organisms Affected
Enteric bacteria and other eubacteria