Sulfamethazole
Brand names,
Sulfamethazole
Analogs
Sulfamethazole
Brand Names Mixture
Sulfamethazole
Chemical_Formula
C9H10N4O2S2
Sulfamethazole
RX_link
No information avaliable
Sulfamethazole
fda sheet
Sulfamethazole
msds (material safety sheet)
Sulfamethazole
Synthesis Reference
No information avaliable
Sulfamethazole
Molecular Weight
270.333 g/mol
Sulfamethazole
Melting Point
208 oC
Sulfamethazole
H2O Solubility
1050 mg/L
Sulfamethazole
State
Solid
Sulfamethazole
LogP
2.968
Sulfamethazole
Dosage Forms
Tablet
Sulfamethazole
Indication
For the treatment of urinary tract infection
Sulfamethazole
Pharmacology
Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfamethazole
Absorption
Rapidly absorbed.
Sulfamethazole
side effects and Toxicity
No information avaliable
Sulfamethazole
Patient Information
Sulfamethazole
Organisms Affected
Enteric bacteria and other eubacteria