Sulfa Gram
Brand names,
Sulfa Gram
Analogs
Sulfa Gram
Brand Names Mixture
Sulfa Gram
Chemical_Formula
C9H10N4O2S2
Sulfa Gram
RX_link
No information avaliable
Sulfa Gram
fda sheet
Sulfa Gram
msds (material safety sheet)
Sulfa Gram
Synthesis Reference
No information avaliable
Sulfa Gram
Molecular Weight
270.333 g/mol
Sulfa Gram
Melting Point
208 oC
Sulfa Gram
H2O Solubility
1050 mg/L
Sulfa Gram
State
Solid
Sulfa Gram
LogP
2.968
Sulfa Gram
Dosage Forms
Tablet
Sulfa Gram
Indication
For the treatment of urinary tract infection
Sulfa Gram
Pharmacology
Sulfamethizole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulfa Gram
Absorption
Rapidly absorbed.
Sulfa Gram
side effects and Toxicity
No information avaliable
Sulfa Gram
Patient Information
Sulfa Gram
Organisms Affected
Enteric bacteria and other eubacteria