Salicylate
Brand names,
Salicylate
Analogs
Salicylate
Brand Names Mixture
Salicylate
Chemical_Formula
C15H21N3O2
Salicylate
RX_link
http://www.rxlist.com/cgi/generic3/physostigmine.htm
Salicylate
fda sheet
Salicylate
msds (material safety sheet)
Salicylate
Synthesis Reference
Zhang J,et al. Appl Microbiol Biotechnol. 44(5):568-75.
Salicylate
Molecular Weight
275.346 g/mol
Salicylate
Melting Point
105.5 oC
Salicylate
H2O Solubility
7760 mg/L
Salicylate
State
Solid
Salicylate
LogP
1.582
Salicylate
Dosage Forms
Liquid
Salicylate
Indication
For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.
Salicylate
Pharmacology
Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma. Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. Physostigmine can reverse both central and peripheral anticholinergia.
Salicylate
Absorption
No information avaliable
Salicylate
side effects and Toxicity
Side effects include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth, blurred vision or change in near or distant vision, and eye pain.
Salicylate
Patient Information
No information avaliable
Salicylate
Organisms Affected
Humans and other mammals