Antilirium
Brand names,
Antilirium
Analogs
Antilirium
Brand Names Mixture
Antilirium
Chemical_Formula
C15H21N3O2
Antilirium
RX_link
http://www.rxlist.com/cgi/generic3/physostigmine.htm
Antilirium
fda sheet
Antilirium
msds (material safety sheet)
Antilirium
Synthesis Reference
Zhang J,et al. Appl Microbiol Biotechnol. 44(5):568-75.
Antilirium
Molecular Weight
275.346 g/mol
Antilirium
Melting Point
105.5 oC
Antilirium
H2O Solubility
7760 mg/L
Antilirium
State
Solid
Antilirium
LogP
1.582
Antilirium
Dosage Forms
Liquid
Antilirium
Indication
For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.
Antilirium
Pharmacology
Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma. Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. Physostigmine can reverse both central and peripheral anticholinergia.
Antilirium
Absorption
No information avaliable
Antilirium
side effects and Toxicity
Side effects include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth, blurred vision or change in near or distant vision, and eye pain.
Antilirium
Patient Information
No information avaliable
Antilirium
Organisms Affected
Humans and other mammals